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[DOI] [PubMed] [Google Scholar] 12.Mahmoodpoor A., Hamishehkar H., Shadvar K., Ostadi Z., Sanaie S., Saghaleini S.H., Nader N.D

It has been concluded that bioactivation of AMAP to reactive intermediates which form protein adducts does not trigger the critical downstream events by which reactive metabolites of acetaminophen cause liver injury

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Specifically, in the morphine-induced constipation model mice, we demonstrate that morphine inhibits PVN Glu neuronal activity through MOR, thereby reducing DMV Ach neuronal activity, which leads to decreased small intestinal motility and a reduced transit rate, ultimately manifesting in constipation

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