Preclinical studies in rodents showed that GLP-1 receptor agonists, particularly at high doses, were associated with thyroid C-cell tumors (medullary thyroid carcinoma)
Symptoms range from shakiness and sweating to confusion, seizures, and in severe cases, death
Additionally, a later study by Planes-Muoz found that green tea extract stimulated GLP-1 secretion in enteroendocrine STC-1 cells, with the effect becoming stronger over time, especially after simulated gastrointestinal digestion
GLP-1 Receptor Agonists Related to Body Contouring Surgery The rapid and significant weight loss induced by GLP-1 RAs results in substantial depletion of subcutaneous fat and loss of skin elasticity, leading to pronounced skin laxity and body contour deformities
As more healthy individuals seek AOM prescriptions for cosmetic or preventive reasons, insurers must consider how to interpret such use in underwriting and build an understanding of the nuanced, evolving interplay among pharmacologic intervention, lifestyle behaviors, and long-term outcomes
J Clin Endocrinol Metab 99(7):24772485
