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You should always tell your provider about: Current medications and supplements Known allergies Pre-existing medical conditions When to contact your provider: If you experience a persistent headache, severe muscle weakness, or a rash that lasts longer than 24 hours, please call your provider

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This is often related to the initial adjustment phase or higher dosages

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If you have impaired kidney function, some research suggests these high doses may cause further deterioration, so consult with your doctor before supplementing