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Avasimibe is a specific inhibitor of acyl coenzyme A-cholesterol acyltransferase (ACAT) that catalyzes esterification of free cholesterol

Referencias Lpez-Otn C, et al

As a result, less cells could be damaged

Neurons undergoing ferroptosis release damage-associated molecular patterns (DAMPs) such as high-mobility group box-1 protein (HMGB1), ATP, and exosomes enriched in ACSL4-derived metabolites

Neither molecule has a human lifespan trial

324,325 SREBP-1c is a major regulator of fatty acid synthesis and hepatic SREBP-1c overexpression increases DAG content and PKC translocation that in turn impairs INSR tyrosine kinase activity, thereby inducing hepatic IR