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This, in turn, leads to reduced brain tryptophan concentration, decreased 5-HT levels, and diminished 5-HT receptor binding, which may underlie the 5-HT system dysfunction, impaired neurotransmission, and negative cognitive effects observed in SZ

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For biochemical assays, total liver lipids were extracted using chloroform/methanol (21, v/v)

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Doses above 0.1 mg/day push serum estradiol into the high-premenopausal range, which isn't necessary for symptom relief