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Preclinical data consistently show neuroprotective effects, though the dedicated EVOKE trial of semaglutide for Alzheimer's disease found no significant benefit

Moreover, challenges such as weak mechanical stability under physiological conditions, sterilization-related degradation, and high production costs hinder industrial scalability [487,488,489]

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doi: 10.1016/j.canlet.2018.01.008 111 YanHBuP

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