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High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism

doi: 10.1002/hep.32598 69

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When activated, NRF2 ramps up phase 2 detox enzymes (helping eliminate toxins from pollution, smoke, plastics) and turns down phase 1 enzymes that convert substances like grilled-meat char into carcinogens Sulforaphane also boosts glutathione, your brains most powerful antioxidant, far surpassing vitamin C or E It's abundant in broccoli sprouts, but you can also supplement (Rhondas personal choice is Avmacol Extra Strength) | FoundMyFitness

However, this effect has been observed in one scientific study so far, so more tests are required to confirm it fully

Peripheral neurons and adipocytes seem to be significantly affected.25-28 The dideoxynucleosides stavudine and didanosine have been shown to produce significant depletion of mitochondrial DNA in both of these tissues.29,30 The cohort we chose to study consisted of HIV-infected patients exhibiting neurologic toxicity from either stavudine and/or didanosine so that we might examine the effects of micronutrient supplementation on HIV disease progression and on one clinical manifestation of mitochondrial toxicity: distal symmetrical polyneuropathy (DSP)