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However, clinical trials in humans have demonstrated mixed results

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found that Amuc_1100 can improve chronic unpredictable mild stress (CUMS)-induced depression-like behavior and CUMS-induced downregulation of serotonin in the serum and colon of mice, restore gut dysbiosis, upregulate BDNF, and inhibit inflammation in the hippocampus ( 80 , a truncated protein with 80 amino acids truncated at the N-terminus of Amuc_1100, shows a better antidepressant effect on modifying CUMS-induced depression-like behavior in mice than Amuc_1100 does ( A

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