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By influencing S-adenosylmethionine (SAM) levels, it also plays a role in epigenetic regulation and longevity-related gene expression, linking energy metabolism with cellular lifespan

Researchers consulting recent reviews (PMID 41966639) should attend to the regulatory framing as much as the mechanism framing

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Dominance of Animal Studies: 35 out of 36 studies in a major systematic review were animal or cell studies, with only one study involving humans

Reactive oxygen species dependent hypertension in dopamine D2 receptor-deficient mice