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They primarily exert metabolic integration functions through activation of the nuclear receptor farnesoid X receptor (FXR) and the membrane G protein-coupled bile acid receptor 5 (TGR5) ( FXR is widely expressed in the liver and intestine and serves as a feedback sensor for bile acid synthesis

The Danish drugmaker's oral semaglutide, the active ingredient in its obesity injection Wegovy and diabetes shot Ozempic, is slated to win approval by the end of the year