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The active ingredient in Zepbound, Tirzepatide , which is also present in the drug Mounjaro, prescribed off-label for weight loss, functions by mimicking glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

doi: 10.1189/jlb.0413196

Jorgensen, W

Its distinct GLP-1 receptor agonist properties help promote satiety and weight loss, offering additional benefits beyond baseline glucose control

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Evening dosing produces more consistent results across the full cycle because GH secretion patterns remain stable regardless of estrogen or progesterone levels