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Nausea signals -arrestin triggers its own downstream signals (ERK/MAPK pathways) in gut and brainstem neurons, which likely contribute to the nausea and vomiting that plagues all GLP-1 drugs
While causality remains debated, GLP-1 receptor agonists associate with increased pancreatitis risk in some populations
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Resveratrol, which is found in a wide variety of plants such as grapes, exhibits potent inhibitory effects towards TYR (89,90)
In addition, the FXR-MAFG pathway suppressed the expression of oxidative stress-related genes, such as HO-1, NQO-1, and transferrin (TF)
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