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Additionally, it has been investigated for potential relevance to conditions like skin inflammation, chronic obstructive pulmonary disease, and metastatic colon cancer, owing to its ability to regulate thousands of human genes, with observed effects on resetting DNA expression patterns

doi: 10.1007/s12038-022-00315-1 26 Georgiou-SiafisSKTsiftsoglouAS

Week 12 (retatrutide ~0.25 mg/week) Reduced appetite within days Sweet-craving reduction commonly reported GI side effects (nausea, occasional vomiting) titrating from baseline Weight loss minimal at this dose