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Importantly, Nrf2 target genes function beyond NADPH regeneration and GSH-dependent reduction of thioredoxin and peroxiredoxin

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The ability of these allelic variants to catalyze the GSH conjugation of reactive metabolites of acetaminophen, clozapine and diclofenac formed by bioactivation in in vitro incubations by human liver microsomes and drug-metabolizing P450 BM3 mutants has been studied [34]

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