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Moreover, N-myristoylation of ARF1 inhibits innate antiviral immune responses against herpes simplex virus1 infection by suppressing STING-induced IFN responses in macrophages while promoting STING-triggered autophagy, suggesting a therapeutic strategy for modulating STING activation ( 168 )

Nat Commun 10:1617 Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B et al (2017) Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway