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A previous study found that abnormally up-regulated transferrin and ferritin in the ovaries of naturally aging rats can cause iron-accumulating oxidative stress and inflammatory aging through the NF-B signaling pathway (43)

In a mouse model of crystal-induced acute kidney injury (AKI), inhibitors of ferroptosis suppressed the expression of pro-inflammatory cytokines and the infiltration of neutrophils into the damaged tissue (98)

Despite recent studies proposing amyloid-beta (A) 2 , tau 3,4 , or neurofilament light chain (NfL) 5 as markers of pathological changes in the brain, current approaches are not well suited for clinical screening during the pre-symptomatic stage

10.1111/jphp.12501 33 GuengerichF

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