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Key finding: Ipamorelin increased lean body mass by 2.1kg, reduced fat mass by 2.7kg, improved body composition ratio by 18%

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While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful

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