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Donna Ryan of the Pennington Biomedical Research Center in New Orleans, also found that more than half of participants moved down at least one body mass index (BMI) category after two years of taking semaglutide (compared to 16% among a placebo group), and 12% reached a healthy BMI (compared to 1% of the placebo group)

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The earliest and most common reaction is mild nausea, which can begin even before the first full day concludes