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Olaparib is a compound that effectively inhibits PARP1 and PARP2, binding to the catalytic domain and preventing the transfer of ADP-ribose units from NAD + to target proteins, thus lowering NAD + consumption 160,161

doi: 10.1038/nature18646 96 PengQ.ChenX.LiangX.OuyangJ.WangQ.RenS.et al

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