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Supplementation with vitamins B6, B12, and folic acid has been shown to significantly reduce homocysteine levels in patients with mild cognitive impairment (MCI), suggesting a potential benefit in managing homocysteine-related cognitive issues

[PMC free article] [PubMed] [Google Scholar] 177.Steranka L.R., Sanders-Bush E

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My own clinical practice is usually a trial of oral replacement initially, checking levels as per the monitoring advice below, and switching to intramuscular replacement where indicated