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307 The JAK/STAT3 signaling pathway, one of the most important modes of STAT signaling, regulates cell function through cytokine-receptor interactions, activation of the JAK protein kinase, and phosphorylation of the STAT protein

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The mediators of cartilage damage include MMPs, a disintegrin-like metalloprotease with thrombospondin type 1 motifs 4 and 5 and cathepsins