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This observation prompted us to investigate the immune-phenotyping contribution of PSPH in GBM

A translational review on NNMT inhibitor clinical development ( Emerging opportunities for NNMT inhibitor clinical translation , ScienceDirect, 2026) points out that alternative routes like polyamine biosynthesis could compensate for the raised SAM, and that partial rather than total inhibition might even be preferable specifically to avoid triggering those compensatory mechanisms from a chronically imbalanced SAM/SAH ratio

Liver & kidney disease or disorders

Ng FM, Jiang WJ, Gianello R, Pitt S, Roupas P

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