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In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47

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For example, instead of one-by-one SNP analysis, Tan and coworkers employed analysis of GWAS data for 54 genes involved in the inositol phosphate metabolic pathway in eight different types of tumors that could potentially pave the way for the GWAS-based analysis of the metabolism-related biomarkers [69]