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The practical impact of metabolic withdrawal: large-scale population studies suggest that individuals who use and then discontinue GLP-1RAs before pregnancy may experience excessive gestational weight gain (GWG) and an increased risk of gestational diabetes mellitus (GDM) and gestational hypertension (137)

Behavioral strategies can also provide relief: Avoid lying down immediately after eating

In 2005, the first GLP-1 receptor agonist received FDA approval in the U.S

Most current evidence is pre-clinical