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The TGR inhibitor demonstrating greatest efficacy in treating infected mice, 2 , was also studied after oral administration: 2 (200 mg/kg p.o.) gave plasma concentrations of 0.71, 0.77, and 0.40 M at 30, 60, and 120 min, respectively (Supplementary Table 19)

Diasio RB (2001) Current status of oral chemotherapy for colorectal cancer

PDK4 has been reported to block a metabolic switch from glycolysis to predominantly fatty acid synthesis and contribute to ferroptosis resistance in certain cancer cells, such as pancreatic ductal adenocarcinoma (PDAC) cells [18,19]

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Natural products derived from plants have shown promising results in thyroid cancer treatment