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Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway

Oxidative stress activates the ASK1-JNK pathway, leading to JNK translocation to mitochondria, further exacerbating mitochondrial damage

It participates in the conversion of homocysteine to methionine and the metabolism of methylmalonic acid, both crucial for energy production at the cellular level

Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus

However, SAS is significantly less potent than erastin

(PubMed) Shouk R, Abdou A, Shetty K, Sarkar D, Eid AH