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Food and Drug Administration (FDA) to treat overweight and obesity
The markets concerns are not about GLP-1s, they are about decelerating same-club sales (guided to 4-5% in 2026, down from 6.7% in 2025), intensifying competition from Crunch Fitness and EoS Fitness in the high-value, low-price segment, and the mechanical revenue drag from selling eight California corporate clubs to franchisees
If the geroscience reframing holds up, the population that benefits from this drug class is much larger than the population that currently qualifies for it
SP might inactivate KEAP1, which allowed NRF2 to escape ubiquitination, accumulate within the cell, and translocate to the nucleus 28
Consequently, the growing obesity pipeline today comprises over 120 weight loss agents which are being developed by 60 companies across multiple mechanisms of action (MoAs) and different formulations, including many orals (see Figure 1)
