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Thus, the enzyme cannot be inhibited by more than 100% and the actions of the incretin hormones are glucose-dependent ( Despite the theoretical potential for multiple endogenous DPP-4 substrates to be affected and for the DPP-4 protein to have diverse actions, as discussed in the sections above, pooled safety analyses (119123), and large cardiovascular (CV) safety outcome trials (124127) with the individual drugs, which between them have included many thousands of patients (Table 2), have uniformly shown that DPP-4 inhibitors are well-tolerated and not generally associated with adverse effects

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Rapid weight loss or prolonged fasting periods due to appetite suppression is likely to be associated with a higher risk of hypoglycemia, and therefore, should be avoided in patients with T1D

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Other Causes of Nipple Soreness While latch issues are the most common cause of nipple pain, other conditions are common and can also contribute to soreness while breastfeeding