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Propensity score was used to 1:1 match for age, sex, ischaemic heart disease, hypertension, microvascular complications, chronic kidney disease, HbA 1c , BMI and use of pioglitazone, lipid modifying agents, antilipemic agents, ACE inhibitors, angiotensin II inhibitors and metformin

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Many titration schedules increase to 12 mg over 8-12+ weeks, though some trial arms used faster or slower steps

That may be a rational design for local GI exposure , where systemic bioavailability may not even be the primary objective