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Activation of RAS ultimately leads to changes in the expression of numerous genes via activation of members of the extracellular signal-regulated kinase (ERK) family of MAPK kinases

This product is intended strictly for laboratory research use only, including in vitro testing and non-clinical experimentation

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It is difficult to draw conclusions from the two studies, as their design and interventions differed

ET-1 mediates its effects through two receptors, ET A and ET B

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