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The highest doses studied 8 mg and 12 mg were associated with the greatest weight loss outcomes in trial data, but also with a higher incidence of side effects

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Combined with a GLP-1 receptor agonist, it has a more significant effect on glucose and body weight effects such as: boosted weight loss, improvements in cardiometabolic measures and reduced appetite

Stopping biologic therapy or immunosuppressants without medical guidance can trigger a flare