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3 One study (an extension of the original STEP-1 trial) also showed that participants regained two-thirds of their weight after discontinuing semaglutide, suggesting that maintaining weight loss may require long-term use
Common Signs of Poor Tolerance Persistent bloating after meals: Stomach feels tight or swollen long after eating Feeling overly full for hours: Prolonged heaviness can indicate slowed digestion Increased nausea: Queasiness triggered specifically after red meat Sulfur burps or reflux: Unpleasant gas or acid movement back into the throat Appetite reduction after eating meat: Feeling uncomfortably full, making it hard to eat other nutritious foods When to Adjust Your Diet If these symptoms occur consistently, it may be time to reduce portion size or switch protein sources
The reduced weight loss in diabetic participants likely reflects insulin resistance and other metabolic factors that attenuate the response
She graduated with her undergraduate degree from the University of Kentucky in 2018 and obtained her Juris Doctorate from the University of Louisville Brandeis School of Law in 2021
What other mechanisms may promote weight loss, and what factors would allow these agents to potentially compete with GLP-1 and GLP-1/GIP receptor agonists
