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Julio Rosenstock I do believe that initial combination therapy with metformin plus a SGLT2 inhibitor or a GLP-1 receptor agonist may become the preferred standard therapy in newly diagnosed type 2 diabetes right from the outset, Julio Rosenstock, MD, director of the Dallas Diabetes Research Center at Medical City and clinical professor of medicine at the University of Texas Southwestern Medical Center in Dallas, said during a presentation

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According to FDA prescribing information, gastrointestinal adverse effects occur in a substantial proportion of patients, particularly during dose initiation and escalation