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These approaches do not account for the fact that complex chronic diseases are driven by multiple distinct biological mechanisms, and that patients have different genetic and comorbidity backgrounds meaning they will respond differently to modulation of GLP-1 pathways

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Mechanisms of ageing and development , 177 , 3745

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The current and emerging anti-obesity treatments constitute long-lasting analogs of intestinal epithelial cellexpressed incretins that signal through their cognate G proteincoupled glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-induced insulinotropic polypeptide (GIP) receptor (GIPR)