Unlike genetic resistance, these phenotypes enable fungal cells to survive high concentrations of antifungals without a measurable increase in minimum inhibitory concentration (MIC), contributing to chronic and relapsing infections ( Cryptococcus can enter a quiescent state that confers high tolerance to AmB (Ke et al., 2024)
Ang L, et al
The honest answer is that it depends on the indication, and the timeline varies enough between tissue types that a single number is misleading
Complementary optical techniques such as ultraviolet-visible (UVVis) spectroscopy, PL spectroscopy, and zeta potential analysis confirm surface and charge-related behaviour (Figure 2) [26, 34]
However, when ERAD is insufficient, autophagy is activated to clear the accumulating proteins
Beyond its calming effects, magnesium is also essential for producing melatonin, the hormone that regulates the sleep-wake cycle