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The PANK4 gene is expressed at highest levels in skeletal muscle

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Moreover, it contributes to the brain's protection against oxidative degeneration by elevating glutathione levels, a crucial antioxidant, by amplifying c-glutamyl transpeptidase gene expression [29]

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349 Aging-related nuclear NAD + decline inhibits the mitochondrially encoded genes via the SIRT1-HIF-1-c-Myc pathway, while boosting NAD + levels rescues the mitochondrial function in old mice in a SIRT1-dependent manner

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