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Pregnancy INCREASES toxicity risk : 80% increase in toxic NAPQI production, 43% higher in first trimester, 33% decrease in safe pathway, and glutathione depleted 36-87%

Specific markers are used to distinguish and diagnose systemic mastocytosis, including the World Health Organization criteria

Regular exercise, stress management techniques, and adequate sleep are also important for maintaining optimal glutathione levels

[Abstract] Brain Res Bull

Several factors contribute to this decline

Balakumaran, Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India