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14 Severe gastrointestinal issues Patients with severe gastrointestinal issues - inflammatory bowel disease, gastroparesis, history of gastrointestinal surgery

A 2021 review of NNMT as a metabolic target stated plainly that clinical trials targeting NNMT have not been reported until now (Liu 2021, PMID 34368359) [5], and that held into 2026

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and the activities of LDL-C, TBA, and TG were significantly decreased in the liver

Target at least 0.7-1.0 grams of protein per pound of goal body weight daily