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This improvement in insulin sensitivity is one reason semaglutide produces weight loss even in people without diabetes

If the symptoms do not resolve within the appropriate time after you start taking the medication and fatigue persists, we recommend contacting your doctor to discuss managing fatigue in your unique case

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Electrical stimulation of the OB induces electrophysiological responses in the LH and the PVN 36,37 , many of the structures to which the OB projects via the MCs, such as the AON, the olfactory tubercle and the piriform cortex, also project to the LH 37,38,39