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As FOXO proteins constitute key components of the insulin signaling pathway, the impact of drugs regulating its action significantly influences blood sugar levels [115]
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Similarly, T2D upregulates the expression of acetylcholinesterase (AChE), and suppresses that of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) while enhancing the expression of TNF, IL-1, IL-6, NF-B, and caspase-3 and production of malonaldehyde (MDA) and subsequent progression of CD
doi: 10.1530/EC-18-0099 2 MollerNJorgensenJO
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