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This binding depends on the intact N-terminal hexapeptide sequencemechanical shear stress from shaking or direct powder impact can break peptide bonds in that sequence, reducing receptor binding affinity by 1540%

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PMID: 31958096 In this study, the researchers used a classical neurotoxin model (MPTP) of Parkinsons and compared a new GLP-1/GIP receptor dual agonist (called DA-CH5) with a well characterised GLP-1R agonist called Liraglutide