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In vitro , SGLT2 exhibited antitumor activity by augmenting caspase 3 cleavage activity and modulating the expression of Bax/Bcl-2 (Xie et al., 2020)

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248 Notably, ER-phagy becomes activated to degrade high-molecular-weight proinsulin aggregates in ERAD-deficient cells

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Additionally, another study demonstrated that dsDNA-triggered cGAS-STING signaling augmented the migratory and invasive capabilities of RA-FLSs, which were suppressed by cGAS or STING short hairpin RNA treatment (64)