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Cisplatin-resistant OSCC cells suppress ferroptosis through upregulation of the SLC7A11-GSH-GPX4 axis, while reactivating ferroptosis can restore cisplatin sensitivity and reverse the resistant phenotype ( inhibitor erastin promotes ferroptosis via a ROS-dependent mechanism, enhances cisplatin cytotoxicity in OSCC cells, and exhibits no overt toxicity in vivo , providing a clinically translatable approach to overcome cisplatin resistance

Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice

PMID: 41468591

Endocrinology 149 , 31673175 (2008)

Add diluent slowly by directing it down the vial wall rather than directly onto the powder pellet

Hence, alterations of CTS levels in bloodstream significantly affect the functionality of blood cells, contributing to the organisms adaptive response