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A 2020 study found that the death rate among people with the highest levels of B12 in their bodies was almost twice as high as that of people with the lowest levels of B12

Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025

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Hyperthyroidism complications: Thyroid crisis (thyroid storm): a rare but life-threatening condition characterized by extremely high levels of thyroid hormones, leading to fever, tachycardia, and confusion (Singh 2024)

10.1038/35017038 2 ChenL

Individuals with gastrointestinal disorders , like Crohn's or celiac disease