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Evidence supports a weight loss threshold of approximately 710% for changes in bone metabolism [7, 9]

Houston 2011

1 2 "Regulation of Sulphur Assimilation Is Essential for Virulence and Affects Iron Homeostasis of the Human-Pathogenic Mould Aspergillus fumigatus"

(PubMed) Byun E, Lim JW, Kim JM, Kim H

Figure 30C)

This distinction gets emphasized throughout peptide research literature for good reason: mechanical agitation from shaking can physically disrupt the bonds holding a peptides amino acid chain together, a form of damage that cant be reversed once it occurs