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They have come into the limelight after a large double-blinded study published in NEJM, showed an average 14.9% decrease in weight in obese patients given semaglutide on top of lifestyle modifications, compared to 2.4% in the control arm (see research summary at end)

The future of GLP-1 drugs looks promising, with ongoing research into oral formulations and combination therapies

Lv M, Xue G, Cheng H, et al

These results may suggest that GLP-1R agonists may alleviate the bloodbrain barrier breakdown induced by inflammatory factors, which is sometimes observed in depression [65]

A.HashimK

World J Gastroenterol (2018) 24:336173