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Contraindications : It should not be used in patients with a history of medullary thyroid carcinoma, MEN2, severe gastroparesis, pregnancy, or uncontrolled GI disease

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Epithalon is a synthetic tetrapeptide, a four amino acid peptid, that mirrors Epithalamin, the naturally occurring polypeptide secreted in the epithalamium-epiphyseal region of the brain (the pineal gland area)

These results imply that RS is related to aberrations in both excitatory and inhibitory synaptic transmission [337]

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Although more large trials are needed, the existing data underline its role in brightening protocolsespecially when oral or topical routes fall short