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If we do not have enough folic acid, the body can make abnormally large red blood cells that do not work properly

Here it is also useful to note that vegetarianism, and any concomitant vitamin B 12 deficiency, have presumably been around for several centuries in the Indian subcontinent, while the growth of diabetes is relatively recent in the last few decades

This results in cell signaling through downstream kinases AMP-activated protein kinases (AMPK) (792), protein kinase Akt (791), and mitogen-activated protein kinase (MAPK)(791) which ultimately regulates angiogenesis (ubiquitin ligase Siah (Siah1/2) and hypoxia-inducible factor 1 (HIF1) (793)), insulin sensitivity (glucose transporter 4 (Glut4)(794)), re-vascularization (Rac1(795)), and vasodilation (COX(796), endothelial nitric oxide synthase (eNOS)(797,798))

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