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It is deliberately membrane-permeable, which is what lets it get inside cells and act on an intracellular enzyme

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Mistakes I see repeatedly: On the topical side: applying to damp skin, layering acids immediately, using too little product (a barely-visible film isn't enough), and leaving reconstituted products at room temperature for weeks

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Intracellular transport and regulation of transcytosis across the bloodbrain barrier

Magnetic Resonance Imaging , 23 (2), 159165