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The liver-derived hormone hepcidin serves as the principal regulator of systemic iron homeostasis by binding to FPN1 on the surface of enterocytes and other cell types, thereby inducing its internalization and degradation and ultimately inhibiting iron entry into the bloodstream (Tayal et al., 2025)

Strict administration requirements Oral semaglutide must be taken on an empty stomach, and patients must wait at least 30 minutes before eating, drinking, or taking other oral medications

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Mori H, Kuroda A, Ishizu M, et al